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Join us as we delve into the perilous world of 2,4-Dinitrophenol (DNP) poisoning, a dangerous "fat-burner" making an alarming comeback. We explore two compelling case studies that illuminate the catastrophic effects of "runaway uncoupling," where DNP's potent mitochondrial disruption leads to extreme hypermetabolism and a devastating, self-amplifying chain reaction. Discover the clinical challenges and intensive care strategies required to combat this unpredictable and often fatal toxin.